Stem Cell Factor and Hematopoiesis

Stem cell factor and hematopoiesis.

HEMATOPOIESIS AND STEM CELLS Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function

1Department of Pediatrics, Washington University, St Louis, MO; 2Department of Medicine, University of Florida, Gainesville, FL; 3Department of Medicine, Siteman Cancer Center, Washington University, St Louis, MO; and 4Department of Biology of Aging, Section Stem Cell Biology, European Research Institute for the Biology of Aging, University Medical Center Groningen, University of Groningen, Gro...

HEMATOPOIESIS AND STEM CELLS The transcription factor Srf regulates hematopoietic stem cell adhesion

Adhesion properties of hematopoietic stem cells (HSCs) in the bone marrow (BM) niches control their migration and affect their cell-cycle dynamics. The serum response factor (Srf) regulates growth factor–inducible genes and genes controlling cytoskeleton structures involved in cell spreading, adhesion, and migration. We identified a role for Srf in HSC adhesion and steady-state hematopoiesis. C...

HEMATOPOIESIS AND STEM CELLS cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis

The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking among the defined hematopoietic organs. However, the physiologic mechanisms that regulate HSC mobilization remain elusive. Through analysis of the zebrafish cmyb mutant cmybhkz3, we show that the suppression of cMyb function abrogates la...

Human interleukin-4 enhances stromal cell-dependent hematopoiesis: costimulation with stem cell factor.

Interleukin-4 (IL-4) has distinct hematopoietic activities, primarily as a costimulant with other cytokines to enhance colony formation of hematopoietic progenitors. We investigated the influence of IL-4 on stromal cell-supported long-term cultures (LTCs) of normal human bone marrow. Addition of IL-4 to LTCs of unseparated bone marrow or highly enriched CD34+ cells resulted in a significant inc...